All three major indexes were down, though barely. The Dow Jones industrial average fell 40.27 points, or 0.3 percent, to 13,553.10.
U.S. stocks are coming off a surge last week that sent the S&P 500 to its highest level in nearly five years. Investors bought stocks on news that the Federal Reserve planned to buy mortgage bonds in an effort to get people to borrow and spend more.
Dampening investor spirits was an Empire State Manufacturing Survey suggesting that conditions for New York manufacturers continued to weaken in September. That followed news from the Fed on Friday that U.S. industrial production fell in August by the largest amount in more than three years.
"We're not completely out of the woods economically, and that's weighing on markets," said Wasif Latif, vice president of equity investments at USAA Investments. He added that, as indexes hover at multi-year highs, "psychological barriers and technical barriers may be tough to breach."
Apple rose $8.50, or 1.2 percent, to $699.78, a new high for the stock market's most valuable company. The company said advance sales for its iPhone 5 available later this week are running at double the rate for its previous version of the phone.
The Standard & Poor's 500 index fell 4.58 to 1,461.19. The Nasdaq composite lost 5.28 to 3,178.67.
Six of the 10 major industry sectors in the S&P 500 fell, led by materials stocks, down 1.5 percent. Banks and other financial companies were also hit hard, down 1.1 percent.
Energy stocks lost 0.8 percent, climbing back from steeper losses in the afternoon following a plunge in oil that left traders guessing as to the cause. Benchmark crude fell to $96.62, a loss of $2.38, or 2.4 percent, the biggest fall since late July.
U.S. stocks began their decline at the opening bell, following overseas markets lower. Benchmark indexes fell 0.8 percent in France and 0.9 percent in Italy.
Investors in Europe sold partly on signs that setting up a new authority overseeing European banks could take longer than expected following a disappointing meeting of the region's financial ministers over the weekend. The new authority would be able to bail out banks directly. Investors are worried that collapsing banks could spread panic, leading to a breakup of the monetary union.
Among stocks making big moves Monday, Office Depot Inc. rose 13 cents, or 5 percent, to $2.60 after an investment firm pushing for changes at the office-supply chain announced it had become the retailer's largest shareholder.
More than two stocks fell for every one that rose on the New York Stock Exchange. Volume was light at 3.2 billion shares.
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